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LATEST DIALOGUES Cellular Healing of Inherited Trauma

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Our life experiences may be passed on to our children and our children’s children through our genes. The open question is, can we make a difference? Will healing our own traumas prevent them being delivered at the baby carriage of our grandchildren? Scientists are now revealing that they have discovered how this genetic inheritance can be turned on or off. The good news: healing personal trauma will make a huge difference to future generations.

According to epigenetics — the study of inheritable changes in gene expression not directly coded in our DNA — our life experiences may be passed on to our children and our children’s children. Studies on survivors of traumatic events have suggested that exposure to stress may indeed have lasting effects on subsequent generations. But how exactly are these genetic “memories” passed on?

A new Tel Aviv University study pinpoints the precise mechanism that turns the inheritance of environmental influences “on” and “off.” The research, published last week in Cell and led by Dr. Oded Rechavi and his group from TAU’s Faculty of Life Sciences and Sagol School of Neuroscience, reveals the rules that dictate which epigenetic responses will be inherited, and for how long.

“Until now, it has been assumed that a passive dilution or decay governs the inheritance of epigenetic responses,” Dr. Rechavi said. “But we showed that there is an active process that regulates epigenetic inheritance down through generations.”

Passing stress from one generation to the next

Researchers have been preoccupied with how the effects of stress, trauma, and other environmental exposures are passed from one generation to the next for years. Small RNA molecules — short sequences of RNA that regulate the expression of genes — are among the key factors involved in mediating this kind of inheritance. Dr. Rechavi and his team had previously identified a “small RNA inheritance” mechanism through which RNA molecules produced a response to the needs of specific cells and how they were regulated between generations.

“We previously showed that worms inherited small RNAs following the starvation and viral infections of their parents. These small RNAs helped prepare their offspring for similar hardships,” Dr. Rechavi said. “We also identified a mechanism that amplified heritable small RNAs across generations, so the response was not diluted. We found that enzymes called RdRPs are required for re-creating new small RNAs to keep the response going in subsequent generations.”

Most inheritable epigenetic responses in C.elegans worms were found to persist for only a few generations. This created the assumption that epigenetic effects simply “petered out” over time, through a process of dilution or decay.

“But this assumption ignored the possibility that this process doesn’t simply die out but is regulated instead,” said Dr. Rechavi, who in this study treated C.elegans worms with small RNAs that target the GFP (green fluorescent protein), a reporter gene commonly used in experiments. “By following heritable small RNAs that regulated GFP — that ‘silenced’ its expression — we revealed an active, tuneable inheritance mechanism that can be turned ‘on’ or ‘off.'”

The scientists discovered that specific genes, which they named “MOTEK” (Modified Transgenerational Epigenetic Kinetics), were involved in turning on and off epigenetic transmissions.

“We discovered how to manipulate the transgenerational duration of epigenetic inheritance in worms by switching ‘on’ and ‘off’ the small RNAs that worms use to regulate genes,” said Dr. Rechavi. “These switches are controlled by a feedback interaction between gene-regulating small RNAs, which are inheritable, and the MOTEK genes that are required to produce and transmit these small RNAs across generations.

“The feedback determines whether epigenetic memory will continue to the progeny or not, and how long each epigenetic response will last.”

A comprehensive theory of heredity?

Although their research was conducted on worms, the team believes that understanding the principles that control the inheritance of epigenetic information is crucial for constructing a comprehensive theory of heredity for all organisms, humans included.

“We are now planning to study the MOTEK genes to know exactly how these genes affect the duration of epigenetic effects,” said Leah Houri-Zeevi, a PhD student in Dr. Rechavi’s lab and first author of the paper. “Moreover, we are planning to examine whether similar mechanisms exist in humans.”


You might also enjoy: The Breadcrumb Trail of Inherited Family Trauma

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Georgi is a teacher, writer and therapist living in Israel. She is author of the book I AM HERE - Opening the Windows of Life and Beauty which is an inquiry into the perceptive windows of consciousness, awareness and perception through emptiness.

3 Responses to “Cellular Healing of Inherited Trauma”

  1. July 14, 2016 at 6:50 am, leesajohnson said:

    Excellent ideas!! Thank you for sharing.Genetic, environmental, nutritional and psychological factors all play a role. Your mind is a very powerful thing, and it’s first and foremost job is to protect you. When you are suffering from trauma, it will try to “disconnect” and dampen the effects as much as it can so you can continue functioning and surviving. Because life doesn’t stop after it’s over and you know you have to carry on. Sometimes it does that by locking your memory into your subconscious so it can’t hurt you anymore.

  2. July 17, 2016 at 9:20 am, Diane de Simone said:

    “When I let go of what I am I become what I might be.” Lao Tzu
    Healing inherited Trauma as well as one’s own trauma is absolutely key to allowing, offering, freedom to ourselves and our loved ones. The most powerful tool I’ve come across and used is The Presence Process by Michael Brown….A truly opening up book; a self-facilitated course. This work enters all of our cells. the psyche, the heart.. Look it up. It gently transforms. Most people say there’s one’s life before the Presence Process and then one’s life after. It’s a true gift,

  3. July 21, 2016 at 8:32 am, Stagnaro said:

    Strangely enough, people in every country of the world, both
    in the East and in the West, seemingly ignore the beautiful Manuel’s Story, This is the Story of Manuel, first newborn with negative Oncological Terrain, from parents both with positive OT, but successfully healed before the beginning of pregnancy. Manuel corroborates, from the clinical view-point, Andras Pellioniz’s The Principle of fractalic Recursive Genome Function.

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